Icaritin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

淫羊藿素具有激素调节活性和心血管功能改善活性。淫羊藿素具有抗癌活性，可诱导S期阻滞和细胞凋亡，抑制ENKL细胞增殖。

Icaritin is an oral traditional Chinese medicine, derived from barrenwort, which targets the estrogen receptor α36. IC50 values for Icaritin are 8,13 and 18 μM for K562, CML-CP and CML-BC cells respectively. Icaritin inhibits the invasion and epithelial-to-mesenchymal transition of glioblastoma cells by targeting EMMPRIN via PTEN/AKt/HIF-1α signalling. Icaritin suppresses hepatocellular carcinoma initiation and malignant growth through the IL-6/Jak2/Stat3 pathway. Icaritin activates JNK-dependent mPTP necrosis pathway in colorectal cancer cells.

Cell Proliferation Assay Cell Line:K562, imatinib-resistant cells and primary CML cells Concentration:4 μM, 8 μM, 16 μM, 32 μM and 64 μM Incubation Time:48 hours Result:Inhibited cell proliferation.Apoptosis Analysis Cell Line:K562 or primary cells Concentration:0 μM, 4 μM, 8 μM, 16 μM, 32 μM and 64 μM Incubation Time:48 hours Result:Induced K562 or primary cells apoptosis.Cell Cycle Analysis Cell Line:K562 cells Concentration: 32 μM Incubation Time:Result:Cell population in the sub-G1 phase was increased.Western Blot Analysis Cell Line:K562 cells Concentration:0 μM, 4 μM, 8 μM, 16 μM, 32 μM and 64 μM Incubation Time:48 hours Result:Inhibited MAPK/ERK/JNK downstream signaling and diminishes Jak2/Stat3/Akt expression.

Animal Model:Female NOD-SCID nude mice (6-8 weeks old) with K562 cells Dosage:4 mg/kg and 8 mg/kg Administration:Intraperitoneal injection; daily; for 10 weeks Result:Could prolong lifespan of NOD-SCID nude mice inoculated with K562 cells without suppression of bone marrow.

Icaritin

Others

Other Targets

JAK2| STAT3

Cancer

——

118525-40-9

368.38

C21H20O6

>98% (HPLC)

DMSO : 14 mg/mL 38.00 mM;

CC(=CCc1c(cc(c2c1oc(c(c2=O)O)c1ccc(cc1)OC)O)O)C

3,5,7-Trihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one

(-20℃)

With Ice Pack

≥ 2 years