Endoxifen HCl ( Z-Endoxifen HCl | Z Endoxifen HCl | ZEndoxifen Hydrochloride )

产品货号. M17762 CAS No. 1032008-74-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Endoxifen HCl
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Endoxifen HCl 是他莫昔芬的活性代谢物，它是一种有效的选择性雌激素受体拮抗剂。
产品描述

Z-Endoxifen HCl is an estrogen receptor alpha (ERalpha) ligand, potent antiestrogen, and metabolite of tamoxifen. Z-endoxifen is the most potent of the metabolites of tamoxifen, and has the potential to be more effective than tamoxifen because it bypasses potential drug resistance mechanisms attributable to patient variability in the expression of the hepatic microsomal enzyme CYP2D6.
体外实验

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体内实验

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同义词

Z-Endoxifen HCl | Z Endoxifen HCl | ZEndoxifen Hydrochloride
通路

Membrane Transporter/Ion Channel
靶点

Sodium Channel
受体

ER
研究领域

Cancer
适应症

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CAS Number

1032008-74-4
分子量

409.95
分子式

C25H28ClNO2
纯度

>98% (HPLC)
溶解度

DMSO : 12.5 mg/mL 30.49 mM; H2O : < 0.1 mg/mL
SMILES

CC/C(=C(\c1ccc(cc1)O)/c1ccc(cc1)OCCNC)/c1ccccc1.Cl
化学全称

4-[(Z)-1-[4-[2-(Methylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol hydrochloride

1. Chae YJ, et al. Endoxifen, the active metabolite of tamoxifen, inhibits cloned hERG potassium channels. Eur J Pharmacol. 2015 Apr 5;752:1-7.

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