APD597 ( APD597 | APD-597 | APD 597 | JNJ-38431055 )

产品货号. M17648 CAS No. 897732-93-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

APD597
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

APD597 是一种 GPR119 激动剂，用于治疗 2 型糖尿病。
产品描述

APD597, also known as JNJ-38431055, is a potent and selective GPR119 agonist, which is potential useful for the treatment of type 2 diabetes. GPR119 agonists mediate a unique nutrient-dependent dual elevation of both insulin and glucagon like peptide 1/glucose-dependent insulinotropic peptide levels in vivo.
体外实验

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体内实验

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同义词

APD597 | APD-597 | APD 597 | JNJ-38431055
通路

Proteasome/Ubiquitin
靶点

Serine Protease
受体

GPR119
研究领域

Metabolic Disease
适应症

——

CAS Number

897732-93-3
分子量

479.55
分子式

C21H29N5O6S
纯度

>98% (HPLC)
溶解度

DMSO : ≥ 19 mg/mL; 39.62 mM
SMILES

Cc1c(ccc(n1)S(=O)(=O)C)Nc1c(c(ncn1)OC1CCN(CC1)C(=O)OC(C)C)OC
化学全称

isopropyl 4-((5-methoxy-6-((2-methyl-6-(methylsulfonyl)pyridin-3-yl)amino)pyrimidin-4-yl)oxy)piperidine-1-carboxylate

1. Buzard DJ, et al. Bioorg Med Chem Lett. 2014 Sep 1;24(17):4332-5.

计算器

产品手册

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