Vorapaxar sulfate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Vorapaxarsulfate 是一种有效的口服活性凝血酶受体 (PAR-1) 拮抗剂。

Vorapaxar sulfate is a potent and orally active thrombin receptor (PAR-1) antagonist.(In Vitro):Vorapaxar sulfate (SCH 530348 sulfate) shows potent inhibition of thrombin-induced platelet aggregation with an IC50 of 47 nM and haTRAP-induced platelet aggregation with an IC50 of 25 nM. Vorapaxar sulfate (SCH 530348 sulfate) inhibits thrombininduced calcium transient in human coronary artery smooth muscle cells (HCASMC) with a Ki of 1.1 nM. It also inhibits thrombin-stimulated thymidine incorporation in HCASMC with a Ki of 13 nM.

Vorapaxar sulfate (SCH 530348 sulfate) shows potent inhibition of thrombin-induced platelet aggregation with an IC50 of 47 nM and haTRAP-induced platelet aggregation with an IC50 of 25 nM. Vorapaxar sulfate (SCH 530348 sulfate) inhibits thrombininduced calcium transient in human coronary artery smooth muscle cells (HCASMC) with a Ki of 1.1 nM. It also inhibits thrombin-stimulated thymidine incorporation in HCASMC with a Ki of 13 nM.

——

——

Others

Other Targets

PAR-1

——

——

705260-08-8

590.66

C29H35FN2O8S

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (211.63 mM)

S(=O)(=O)(O)O.Fc1cc(c2cnc(/C=C/[C@@H]3[C@H]4[C@@H](C[C@H]5[C@H]3CC[C@@H](NC(=O)OCC)C5)C(=O)O[C@@H]4C)cc2)ccc1

——

(-20℃)

With Ice Pack

≥ 2 years