Tectorigenin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

鸢尾皂甙元是一种 O-甲基化异黄酮。鸢尾皂甙元促进成骨细胞分化和体内骨愈合。

Tectorigenin is an O-methylated isoflavone. Tectorigenin Promotes Osteoblast Differentiation and in vivo Bone Healing, but Suppresses Osteoclast Differentiation and in vivo Bone Resorption. Tectorigenin attenuates the MPP⁺-induced SH-SY5Y cell damage, indicating a potential beneficial role in Parkinson's disease by oxidative stress inhibition.

Tectorigenin is a plant isoflavonoid originally isolated from the dried flower of Pueraria thomsoniiBenth. Palmitic acid (PA)-stimulated ROS production is abolished by treatment with Tectorigenin for HUVECsin a dose-dependent manner (0.1, 1, 10 μM). Treatment with Tectorigenin attenuates enhanced IKKβ phosphorylation and effectively blocks NF-κB activation by inhibition of p65 phosphorylation at concentrations ranging from 0.1 to 10 μM. Tectorigenin treatment also effectively inhibits PA-augmented TNF-α and IL-6 production in a concentration dependent manner. The number of viable HepG2 cells treated by Tectorigenin decreases in a concentration- and time-dependent manner. When HepG2 cells are treated with Tectorigenin at 5, 10 and 20 mg/L for 24 h, the viability rate is 91%, 79% and 62%, respectively.

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Tectorigenin | K 251T | K251T

PI3K/Akt/mTOR signaling

PI3K

Apoptosis inducer

Others-Field

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548-77-6

300.27

C16H12O6

>98% (HPLC)

DMSO : 150 mg/mL. 499.57 mM;

c1c(c(=O)c2c(c(c(cc2o1)O)OC)O)c1ccc(cc1)O

4',5,7-Trihydroxy-6-methoxyisoflavone

(-20℃)

With Ice Pack

≥ 2 years