Butein

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Butein 是一种植物多酚，是从漆树中分离出来的。它可以抑制蛋白酪氨酸激酶、NF-κB和STAT3的激活，也可以抑制EGFR。

Butein is found in Rhuteic verniciflua and Butea monosperma. It induces cell cycle arrest and apoptosis in lung cancer cells, inhibits vessel spouting from aortic rings, and prevents hepatic stellate cell activation.

Cell Viability Assay Cell Line:HeLa cells Concentration:10, 20, and 40 μM Incubation Time:24, 48, and 72 hours Result:Inhibited cell growth in a dose- and time-dependent manner.Western Blot Analysis Cell Line:HeLa cells Concentration:20 μM Incubation Time:24 hours Result:Decreased phosphorylation of AKT, ERK and p38 co-treatment with Cisplatin (20 μM).

Animal Model:Nude mice (12 female 6- or 7-week old) with subcutaneous tumor xenografts Dosage:2 mg/kg Administration:Intraperitoneally; every 2 days; for 3 weeks Result:Enhanced the antitumor effects of Cisplatin in vivo.

AC1NQY7L | AC1N-QY7L | AC1N QY7L | CCG-208298

Others

Other Targets

EGFR

Cancer

——

487-52-5

272.25

C15H12O5

>98% (HPLC)

DMSO : ≥ 35 mg/mL128.56 mM

c1cc(c(cc1/C=C/C(=O)c1c(cc(cc1)O)O)O)O

(E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one

(-20℃)

With Ice Pack

≥ 2 years