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Glutaminase C-IN-1
CAS No. 311795-38-7
Glutaminase C-IN-1 ( GLS-IN-968 | Glutaminase inhibitor-968 )
产品货号. M17473 CAS No. 311795-38-7
谷氨酰胺酶 C-IN-1 是一种谷氨酰胺酶 C 变构抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥334 | 有现货 |
|
| 5MG | ￥550 | 有现货 |
|
| 10MG | ￥847 | 有现货 |
|
| 25MG | ￥1628 | 有现货 |
|
| 50MG | ￥2678 | 有现货 |
|
| 100MG | ￥3573 | 有现货 |
|
| 200MG | ￥5094 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥563 | 有现货 |
|
生物学信息
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产品名称Glutaminase C-IN-1
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述谷氨酰胺酶 C-IN-1 是一种谷氨酰胺酶 C 变构抑制剂。
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产品描述GLS-IN-968 is an allosteric inhibitor of glutaminase (GLS). It acts by blocking Rho-GTPase-dependent transformation of fibroblasts and suppressing breast cancer cell growth and invasive activity in vitro.
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体外实验Cell Viability Assay Cell Line:MDA-MB231 cells, SKBR3 cells, and NIH 3T3 cells Concentration:10 μM Incubation Time:5 h Result:Inhibited cell growth.
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体内实验Animal Model:SCID mice with P493 B lymphoma cellsDosage:200 μg/mouse Administration:Intraperitoneal injection, daily for 12 days Result:Caused a ~50% reduction in the size of the tumors.
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同义词GLS-IN-968 | Glutaminase inhibitor-968
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通路Others
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靶点Other Targets
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受体Glutaminase C
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研究领域Cancer
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适应症——
化学信息
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CAS Number311795-38-7
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分子量475.43
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分子式C27H27BrN2O
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纯度>98% (HPLC)
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溶解度DMSO : 25 mg/mL. 52.59 mM;
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SMILESCC1(CC2=C(C(Nc3c2c2ccccc2cc3)c2cc(c(cc2)N(C)C)Br)C(=O)C1)C
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化学全称5-[3-Bromo-4-(dimethylamino)phenyl]-2,3,5,6-tetrahydro-2,2-dimethylbenzo[a]phenanthridin-4(1H)-one
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Stalnecker CA, et al. Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells. Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):394-9.
产品手册
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