SB415286

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SB415286 是一种有效的 GSK3α 抑制剂，IC50/Ki 为 78 nM/31 nM，对 GSK-3β 具有同样有效的抑制作用。

SB-415286 is a potent and selective cell-permeable, ATP-competitive inhibitor of GSK3α with an IC50 value of 78 nM (similar potency for GSK3β) and a Ki value of 31 nM. Pharmacological GSK-3 inhibitors are potential drugs for the treatment of neurodegenerative diseases, cancer and diabetes.

SB 415286 (SB-415286) inhibits human GSK-3α with an IC50 of 77.5 nM, and a Ki of 30.75 nM. SB-415286 stimulates glycogen synthesis in the Chang human liver cell line with EC50 of 2.9 μM. SB-415286 stimulates glycogen synthase activity in Chang human liver cells. SB-415286 induces transcription of a β-catenin-LEF/TCF regulated reporter gene in HEK293 cells. SB 415286 (SB-415286, 5-44 μM) attenuates B65 cell loss mediated by 1 mM H2O2. SB-415286 (5-44 μM) causes a significant dose-dependent decrease in the fluorescence intensity of DCF, and attenuates B65 ROS production as mediated by 1 mM H2O2. SB-415286 (5-44 μM) also attenuates ROS production in CGN mediated by 1 mM H2O2. SB-415286 (50 μM) induces a substantial suppression of immunoprecipitated GSK3 activity by 97%.

——

SB-415286 | SB 415286 | SB415286

Angiogenesis

CDK

GSK-3α , GSK-3β

Neurological Disease

——

264218-23-7

359.72

C16H10ClN3O5

>98% (HPLC)

DMSO : ≥ 83.3 mg/mL; 231.57 mM

OC1=C(Cl)C=C(NC2=C(C(=O)NC2=O)C2=C(C=CC=C2)[N+]([O-])=O)C=C1

3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione

(-20℃)

With Ice Pack

≥ 2 years