Emapunil

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Emapunil 是一种抗焦虑化合物，作为外周苯二氮卓受体（也称为线粒体 18 kDa 易位蛋白或 TSPO）的选择性激动剂。

Emapunil is an anxiolytic drug which acts as a selective agonist at the peripheral benzodiazepine receptor, also known as the mitochondrial 18 kDa translocator protein or TSPO.(In Vivo):Emapunil (AC-5216, 0.1-3, 0.003-0.01 and 0.01-0.3 mg/kg, p.o.) produces anti-anxiety effects in the Vogel-type conflict test in rats, and in the light/dark box and social interaction tests in mice.Emapunil (AC-5216, 3-30 mg/kg, p.o.) reduces the immobility time, and this effect was blocked by PK11195.Emapunil (AC-5216, 1-100 mg/kg, p.o.) produces no distinct change in the rat electroencephalogram.Emapunil (AC-5216, 0.3 and 1 mg/kg, i.g.) causes significant suppression of the enhanced anxiety and contextual fear induced in post-TDS rats.Emapunil (AC-5216, 0.3 and 1 mg/kg, i.g.) alleviates the enhanced anxiety and fear response in a time-dependent sensitization (TDS) procedure, a rat PTSD animal model.Emapunil (AC-5216, 0.3 and 1 mg/kg, i.g.) reverses the increased plasma glucose (PG) and decreased insulin (INS) in HFD-STZ rats.

——

Animal Model:Rats.Dosage:0.1-3 mg/kg.Administration:P.O.. Result:Significantly increased the number of shocks that rats received.Significantly increased the time spent in the light compartment but only slightly increased that time at 0.03 mg/kg, p.o. (P<0.1).

AC-5216 | XBD-173

Others

Other Targets

TSPO ligand

Neurological Disease

——

226954-04-7

401.46

C23H23N5O2

>98% (HPLC)

DMSO : 33.33 mg/mL 83.02 mM;

CCN(Cc1ccccc1)C(=O)Cn1c2nc(ncc2n(c1=O)C)c1ccccc1

——

(-20℃)

With Ice Pack

≥ 2 years