ML355

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

ML355是一种特异性、有效的12-脂氧合酶(12-LOX)抑制剂(IC50=0.34 μM)，具有良好的ADME特性。

ML355 is a potent and selective inhibitor of human 12-lipoxygenase.

ML355 inhibits PAR-4 induced aggregation and calcium mobilization in human platelets and reduce 12-HETE in β-cells.

ML355 (1.88-30 mg/kg; i.g.; 2 times per day for two days) strongly inhibits the thrombus formation in mice at higher dose compared to WT controls. Animal Model:C57BL/6 mice Dosage:1.88, 3.75, 7.5, 15, 30 mg/kg Administration:Oral gavage; 2 times per day for two days Result:The thrombus formation in mice was strongly inhibited by higher doses of ML355.

ML355 | ML 355 | ML-355

Others

Other Targets

12-Lipoxygenase

Inflammation/Immunology|Neurological Disease

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1532593-30-8

441.52

C21H19N3O4S2

>98% (HPLC)

DMSO : ≥ 42 mg/mL. 95.13 mM

COC1=CC=CC(=C1O)CNC2=CC=C(C=C2)S(=O)(=O)NC3=NC4=CC=CC=C4S3

N-2-benzothiazolyl-4-[[(2-hydroxy-3-methoxyphenyl)methyl]amino]-benzenesulfonamide

(-20℃)

With Ice Pack

≥ 2 years