Nolatrexed dihydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Nolatrexed DiHClide 是 nolatrexed 的二盐酸盐，是一种具有抗肿瘤活性的水溶性亲脂性喹唑啉叶酸类似物。

Nolatrexed Dihydrochloride is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. This agent also exhibits radiosensitizing activity.

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AG 337 | Thymitaq

Others

Other Targets

Thymidylate synthase

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152946-68-4

357.26

C14H14Cl2N4OS

>98% (HPLC)

DMSO : 41.67 mg/mL. 116.64 mM;

Cc1c(c2c(cc1)[nH]c(N)nc2=O)Sc1ccncc1.Cl.Cl

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(-20℃)

With Ice Pack

≥ 2 years