Protopine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

普托品是一种苄基异喹啉生物碱。它被发现可以抑制组胺 H1 受体和血小板聚集，并起到镇痛剂的作用。

Protopine is discontinued (controlled substance). Protopine is a benzylisoquinoline alkaloid occurring in opium poppy, Corydalis tubers and other plants of the family papaveraceae, like Fumaria officinalis. It has been found to inhibit histamine H1 receptors and platelet aggregation, and acts as an analgesic.

Western Blot Analysis WB Cell Line:HepG2, Huh7 Concentration:10, 20, 40 μM Incubation Time:24 h Result:Induced the cleavage of caspase-3 and caspase-9.Decreased Bcl-2 and Bcl-xl level.Induced the release of mitochondrial protein cytochrome c into the cytosol.

Animal Model:5-hydroxy-DL-tryptophan (5-HTP)-induced mice modelDosage:5, 10, 20 mg/kg Administration:i.p.Result:Increased the number of 5-HTP-induced head twitch response (HTR).Decreased the immobility time tested in the Tail suspension test (TST).

Protopine | Biflorine | Fumarine | Corydinine

PI3K/Akt/mTOR signaling

mTOR

H1 receptor| platelet aggregation

Others-Field

——

130-86-9

353.37

C20H19NO5

>98% (HPLC)

DMSO : 12.5 mg/mL. 35.37 mM;

CN1CCc2cc3c(cc2C(=O)Cc2c(C1)c1c(cc2)OCO1)OCO3

7-Methyl-2,3:9,10-bis(methylenedioxy)-7,13a-secoberbin-13a-one

(-20℃)

With Ice Pack

≥ 2 years