B-Raf inhibitor 1 dihydrochloride ( B-Raf inhibitor 1 dihydrochloride )

产品货号. M17180 CAS No. 1191385-19-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

B-Raf inhibitor 1 dihydrochloride
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

B-Raf 抑制剂 1 是一种有效的选择性 B-Raf 抑制剂。
产品描述

B-Raf inhibitor 1 dihydrochloride is a novel potent and selective B-Raf inhibitor.
体外实验

B-Raf inhibitor 1 (Compound 13) inhibits A375 and HCT-116 proliferation with IC50s of 0.31 and 0.72 μM, respectively. B-Raf inhibitor 1 (Compound 13) binds to and stabilizes B-Raf in a DFG-out, inactive conformation in which the ATP pocket is partially filled by Phe595 and Gly596 from the DFG motif. B-Raf inhibitor 1 (Compound 13) additionally exhibits low micromolar inhibition against wild type B-Raf cell lines, which may be due to off-target kinase activities or alternatively to pan-Raf inhibition, including Raf dimers.
体内实验

——
同义词

B-Raf inhibitor 1 dihydrochloride
通路

Cytoskeleton/Cell Adhesion Molecules
靶点

Akt
受体

B-Raf
研究领域

Cancer
适应症

——

CAS Number

1191385-19-9
分子量

478.94
分子式

C26H19ClN8
纯度

>98% (HPLC)
溶解度

——
SMILES

Cc1c(c2c(cc1)c(ncc2)Nc1ccc(cc1)Cl)Nc1c(cccn1)c1c2c(ncn1)nc[nH]2.Cl.Cl
化学全称

1-N-(4-Chlorophenyl)-6-methyl-5-N-[3-(7H-purin-6-yl)pyridin-2-yl]isoquinoline-1,5-diamine dihydrochloride

1. Wang X, et al. J Med Chem. 2012 Sep 13;55(17): 7332-41.

计算器

产品手册

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