STO-609 acetate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

STO-609 醋酸盐是 Ca2+-钙调蛋白依赖性蛋白激酶激酶的选择性、细胞渗透性抑制剂（Ki：80/15 ng/ml，对于 CaM-KKα/KKβ）；竞争 ATP 结合位点。

STO-609 acetate is selective, cell-permeable inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki: 80/15 ng/ml, for CaM-KKα/KKβ); competes for the ATP-binding site. It displays > 80-fold selectivity over CaMK1/2/4, PKC, MLCK, PKA and p42 MAPK.

STO-609 inhibits the activities of recombinant CaM-KKα and CaM-KKβ isoforms, with Ki values of 80 and 15 ng/mL, respectively, and also inhibits their autophosphorylation activities. STO-609 is highly selective for CaM-KK without any significant effect on the downstream CaM kinases (CaM-KI and -IV), and the IC50 value of the compound against CaM-KII is 10 μg/mL. STO-609 inhibits constitutively active CaM-KKα as well as the wild-type enzyme. In transfected HeLa cells, STO-609 suppresses the Ca2+-induced activation of CaM-KIV in a dose-dependent manner. STO-609 significantly reduces the endogenous activity of CaM-KK in SH-SY5Y neuroblastoma cells at a concentration of 1μg/mL (80% inhibitory rate).

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Autophagy

Autophagy

CaM-KKα| CaM-KKβ

Neurological Disease

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1173022-21-3

374.35

C19H10N2O3·C2H4O2

>98% (HPLC)

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CC(=O)O.c1ccc2c(c1)nc1n2c(=O)c2cccc3c(ccc1c23)C(=O)O

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(-20℃)

With Ice Pack

≥ 2 years