Sal003

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Sal003 是一种有效的细胞渗透性类似物，可抑制 eIF2α 磷酸酶。

SAL-003 is a cell-permeable inhibitor of eIF2α dephosphorylation. SAL003 is an Analog of salubrinal (Cat. No. 2347) with improved aqueous solubility. Sal003?mediated upregulation of eIF2α phosphorylation suppressed cisplatin?induced p53 activation. Furthermore, reduction of eIF2α phosphorylation by PERK knockdown enhanced cisplatin-induced p53 activation and apoptosis.

Apoptosis Analysis Cell Line:HeLa cells Concentration:10 μM Incubation Time:1 hour Result:Phosphorylated eIF2α and thus enhanced SubAB-induced apoptotic signaling.Western Blot Analysis Cell Line:Mouse embryonic fibroblasts (MEFs)Concentration:20 μM Incubation Time:1 hour, 3 hours, 6 hours, 12 hours Result:Sharply increased eIF2α phosphorylation in mouse MEFs.

Animal Model:Rats (300-325g)Dosage:20 μM Administration:Intrahippocampal injection; 8 minutes Result:Impaired contextual memory.

SAL-003 | SAL 003 | SAL003

GPCR/G Protein

Calcium Channel

eIF-2α phosphatase

Cancer

——

1164470-53-4

463.21

C18H15Cl4N3OS

>98% (HPLC)

DMSO : ≥ 100 mg/mL 215.88 mM

c1ccc(cc1)/C=C/C(=O)NC(C(Cl)(Cl)Cl)NC(=S)Nc1ccc(cc1)Cl

3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide

(-20℃)

With Ice Pack

≥ 2 years