KN-92 phosphate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

KN-92 是 KN-93 的无活性衍生物。 KN-93 是 Ca2+/钙调蛋白依赖性激酶 II (CaMKII) 的选择性抑制剂。

KN-92 is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM).

KN-93 (5-50 μM; 24 hours) inhibits LX-2 cell growth and KN-92 (5-50μM; 24 hours) is ineffective in blocking cell growth.The analysis of cell cycle regulator expression reveals that KN-93 rather than KN-92 reduced the expression of p53 and p21. Cell Viability Assay Cell Line:Human hepatic stellate cells (LX-2) Concentration:5-50 μM Incubation Time:24 hours Result:Ineffective in blocking cell growth.

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Others

Other Targets

CaMK

Others-Field

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1135280-28-2

554.98

C24H28ClN2O7PS

>98% (HPLC)

H2O : < 0.1 mg/mL

OP(O)(O)=O.COc1ccc(cc1)S(=O)(=O)Nc1ccccc1CN(C)C\C=C\c1ccc(Cl)cc1

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(-20℃)

With Ice Pack

≥ 2 years