UCPH-101

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

UCPH-101 是兴奋性氨基酸转运蛋白亚型 1 (EAAT1) 的抑制剂，IC50 为 0.66 μM。

UCPH-101 is a selective excitatory amino acid transporter subtype?1 (EAAT1) inhibitor.

UCPH-101 and UCPH-102 inhibit EAAT1 anion currents in a concentration-dependent manner, with KD values of 0.34±0.03 μM (Hill=1.3±0.13, n≥9) for UCPH-101 and 0.17±0.02 μM (Hill=0.97±0.11, n≥7) for UCPH-102. A small but significant decrease in the total expression levels of both HA-EAAT1 and HA-GLAST is observed in cells preincubated with 100 μM UCPH-101 (p=0.048).

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UCPH-101, UCPH 101, UCPH101

Others

Other Targets

EAAT1

Neurological Disease

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1118460-77-7

422.48

C27H22N2O3

>98% (HPLC)

DMSO : ≥ 110 mg/mL 260.37 mM

COC1=CC=C(C=C1)C2C(=C(OC3=C2C(=O)CC(C3)C4=CC=CC5=CC=CC=C54)N)C#N

2-amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile

(-20℃)

With Ice Pack

≥ 2 years