ZLc002 ( ZLc-002 | ZLc 002 )

产品货号. M17030 CAS No. ——

COA

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HNMR

HPLC

MSDS

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产品名称

ZLc002
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

ZLc002 (ZLc-002) 是一种假定的 nNOS 与 NOS1AP 相互作用的小分子抑制剂。
产品描述

ZLc002 (ZLc-002) is a putative small-molecule inhibitor of nNOS interaction with NOS1AP, disrupts neuronal nitric oxide synthase-NOS1AP interaction in intact cells; exhibits anxiolytic-like efficacy in a mouse model of chronic mild stress without altering appetite, general activity, or locomotor activity or interfering with the resting potential of neurons, also inhibits co-immunoprecipitation of NOS1AP with nNOS in hippocampal cells; suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with paclitaxel to reduce tumor cell viability; suppresses formalin-evoked inflammatory pain in rats and reduced Fos protein-like immunoreactivity in the lumbar spinal dorsal horn (4-10?mg/kg i.p.).
体外实验

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体内实验

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同义词

ZLc-002 | ZLc 002
通路

Immunology/Inflammation
靶点

NOS
受体

NOS
研究领域

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适应症

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1. Lee WH, et al. Mol Pain. 2018 Jan-Dec;14:1744806918801224. 2. Zhu LJ, et al. Nat Med. 2014 Sep;20(9):1050-4.

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