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BAY-885
CAS No. ——
BAY-885 ( BAY885 )
产品货号. M16999 CAS No. ——
BAY-885 (BAY885) 是一种高效、选择性 ERK5 (MAPK7) 抑制剂，IC50 为 40 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称BAY-885
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述BAY-885 (BAY885) 是一种高效、选择性 ERK5 (MAPK7) 抑制剂，IC50 为 40 nM。
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产品描述BAY-885 (BAY885) is a highly potent, selective ERK5 (MAPK7) inhibitor with IC50 of 40 nM, shows high selectivity over a panel of 357 kinases (Eurofins panel); strongly inhibits EGF-stimulated MEF2 transcriptional activity in MEF2 reporter assay with IC50 of 115 nM; despite its high potency, BAY-885 failed to inhibit the proliferation of cells with ERK5 genomic amplification (SN12C, SNU-449, MFM-223) or with constitutively active ERK5 signaling (BT-474, SK-BR-3).
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体外实验——
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体内实验——
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同义词BAY885
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通路MAPK/ERK Signaling
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靶点ERK
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受体ERK
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研究领域——
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适应症——
化学信息
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CAS Number——
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分子量515.541
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分子式C25H28F3N7O2
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C(C1=CC=C(OC(F)(F)F)C=C1N)N2CCC(C3=C4C(C=C(N5CCN(C)CC5)C=N4)=NC=N3)CC2
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化学全称(2-amino-4-(trifluoromethoxy)phenyl)(4-(7-(4-methylpiperazin-1-yl)pyrido[3,2-d]pyrimidin-4-yl)piperidin-1-yl)methanone
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Clara Lemos, et al. Abstract 5866: Discovery and profiling of a highly potent and selective ERK5 inhibitor: BAY-885. AACR. 2018.
