Adenosine 5'-triphosphate disodium salt

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

ATP Disodium salt 是一种 P2 嘌呤受体激动剂。

ATP Disodium salt is a P2 purinoceptor agonist.(In Vitro):ATP disodium salt (5mM; 1 hour) co-treatment with LPS (1 μg/ml) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs.ATP disodium salt (2 mM; 0.5-24 hours) induces secretion of interleukin 1β, KC and MIP-2 from bone marrow derived macrophages (BMDMs) in vitro in a caspase-1 activation-dependent manner.ATP disodium salt stimulats cytokine and chemokine secretion and inflammasome activation directly and indirectly induces in vitro neutrophil chemotaxis.(In Vivo):ATP disodium salt (50 mg/kg; i.p.) protects mice against bacterial infection in vivo.ATP disodium salt induces the secretion of IL1β, KC and MIP-2 and neutrophils recruitment in vivo.

ATP disodium salt (5mM; 1 hour) co-treatment with LPS (1 μg/ml) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs.ATP disodium salt (2 mM; 0.5-24 hours) induces secretion of interleukin 1β, KC and MIP-2 from bone marrow derived macrophages (BMDMs) in vitro in a caspase-1 activation-dependent manner.ATP disodium salt stimulats cytokine and chemokine secretion and inflammasome activation directly and indirectly induces in vitro neutrophil chemotaxis.

ATP disodium salt (50 mg/kg; i.p.) protects mice against bacterial infection in vivo.ATP disodium salt induces the secretion of IL1β, KC and MIP-2 and neutrophils recruitment in vivo. Animal Model:Four-week-old Kunming mice (18-22 g) Dosage:50 mg/kg Administration:Intraperitoneal injection, before bacterial (E. coli) challenge Result:Protected mice from bacterial infection.

ATP | NSC 20268

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987-65-5

551.14

C10H14N5O13P3·2Na

>98% (HPLC)

DMSO: <1mg/ml;Water: 100mg/ml(181.44 mM);Ethanol: <1mg/ml

C1=NC2=C(C(=N1)N)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)OP(=O)([O-])OP(=O)(O)[O-])O)O.[Na+].[Na+]

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(-20℃)

With Ice Pack

≥ 2 years