Perindoprilat

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Perindoprilat 是一种血管紧张素转换酶抑制剂。

Perindoprilat is an Angiotensin Converting Enzyme Inhibitor. The mechanism of action of perindoprilat is as an Angiotensin-converting Enzyme Inhibitor.

Perindoprilat (1 μM, 10 days) treatment suppresses the angiotensin II production in HNSCC cells.Perindoprilat (40 μM, 3 days) treatment attenuates mesangial cell fibronectin level.Cell Viability Assay Cell Line:HNSCC cells Concentration:1 μM Incubation Time:10 days Result:Suppressed the angiotensin II production in HNSCC cells (P=0.028).Cell Viability Assay Cell Line:Human mesangial cells Concentration:40 μM Incubation Time:3 days Result:Resulted in decreases in MPCM-stimulated fibronectin levels of 19.4±0.6% (P<0.001) and 21.7±1.0% (P<0.001) for secreted and cell-associated fibronectin levels, respectively.

Perindoprilat (oral gavage; 1.5 mg/kg; once daily; 7 d) treatment improves cardiac function in mice with acute myocardial infarction and reduces the number of apoptotic myocardial cells.Perindoprilat (oral gavage; 1.5 mg/kg; once daily; 7 d) treatment reduces the expression levels of myocardial Bax and Bcl-2 in infarction zones of mice with acute myocardial infarction.Perindoprilat (oral gavage; 1.5 mg/kg; once daily; 7 d) treatment lowers the expression of myocardial TLR4/NF-κB in infarction zones in mice with acute myocardial infarction. Animal Model:C57BL/6J mice underwent coronary ligation Dosage:1.5 mg/kg Administration:Oral gavage; 1.5 mg/kg; once daily; 7 days Result:Exhibited markedly lowered the number of apoptotic myocardial cells in comparison with the acute myocardial infarction group (p<0.05).Animal Model:C57BL/6J mice underwent coronary ligation Dosage:1.5 mg/kg Administration:Oral gavage; 1.5 mg/kg; once daily; 7 days Result:Reduced the gene and protein expression levels of Bax (a myocardial apoptosis gene) in infarction zones in mice with acute myocardial infarction.Animal Model:C57BL/6J mice underwent coronary ligation Dosage:1.5 mg/kg Administration:Oral gavage; 1.5 mg/kg; once daily; 7 days Result:Declined the number of stained NF-κB p50 protein in the nucleus in infarction zones (p<0.05), compared to the acute myocardial infarction group.

S-9780

Endocrinology/Hormones

AChR

AChR| MRP| ACE

——

——

95153-31-4

340.41

C17H28N2O5

>98% (HPLC)

Soluble in DMSO

O=C([C@H]1N(C([C@H](C)N[C@H](C(O)=O)CCC)=O)[C@@]2([H])CCCC[C@@]2([H])C1)O

(2S,3aS,7aS)-1-(((S)-1-carboxybutyl)-L-alanyl)octahydro-1H-indole-2-carboxylic acid

(-20℃)

With Ice Pack

≥ 2 years