SMER-18

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种小分子自噬增强剂，可在哺乳动物细胞中独立于雷帕霉素诱导自噬，并增强自噬底物（如突变型亨廷顿蛋白和 A53T α-突触核蛋白）的清除；降低亨廷顿病模型中的毒性。

A small molecule autophagy enhancer that induces autophagy independently of rapamycin in mammalian cells and enhances the clearance of autophagy substrates such as mutant huntingtin and A53T alpha-synuclein; reduces toxicity in Huntington's disease models.

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SMER18

Autophagy

Autophagy

Autophagy

Neurological Disease

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944153-47-3

287.7409

C16H14ClNO2

>98% (HPLC)

10 mM in DMSO

OC1=C2N=C(C)C=CC2=CC=C1C(NC3=NC=CC(C)=C3)C4=CC=CC=C4[N+]([O-])=O

2-Buten-1-one, 1-(4-chlorophenyl)-3-[(3-hydroxyphenyl)amino]-, (2Z)-

(-20℃)

With Ice Pack

≥ 2 years