Acebilustat
CAS No. 943764-99-6
Acebilustat ( CTX-4430 | EP-501 )
产品货号. M16760 CAS No. 943764-99-6
Acebilusat (CTX-4430, EP-501) 是一种有效的选择性白三烯 A4 水解酶 (LTA4H) 抑制剂,抑制人全血中 LTB4 的产生,IC50 为 64 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ¥501 | 有现货 |
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| 10MG | ¥690 | 有现货 |
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| 25MG | ¥1367 | 有现货 |
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| 50MG | ¥2186 | 有现货 |
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| 100MG | ¥3033 | 有现货 |
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| 200MG | ¥4212 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
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| 1G | 获取报价 | 有现货 |
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| 1 mL x 10 mM in DMSO | ¥561 | 有现货 |
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生物学信息
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产品名称Acebilustat
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Acebilusat (CTX-4430, EP-501) 是一种有效的选择性白三烯 A4 水解酶 (LTA4H) 抑制剂,抑制人全血中 LTB4 的产生,IC50 为 64 nM。
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产品描述Acebilustat (CTX-4430, EP-501)?is a potent and selective leukotriene A4 hydrolase (LTA4H) inhibitor with IC50 of 64 nM for inhibition of LTB4 production in human whole blood; a new once‐daily oral antiinflammatory drug in development for treatment of cystic fibrosis (CF) and other diseases.Cystic Fibrosis,Phase 2 Clinical(In Vitro):Acebilustat (CTX-4430) is a leukotriene A4 hydrolase inhibitor, which is safe and well tolerated in phase 1 trial. Acebilustat is an antiinflammatory drug in development for the treatment of CF and other diseases. It is a potent inhibitor of the enzyme leukotriene A4 hydrolase (LTA4H), which catalyzes the rate-limiting step in the formation of leukotriene B4 (LTB4), a potent chemoattractant and activator of inflammatory immune cells including neutrophils.
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体外实验Acebilustat (CTX-4430) is a leukotriene A4 hydrolase inhibitor, which is safe and well tolerated in phase 1 trial. Acebilustat is an antiinflammatory drug in development for the treatment of CF and other diseases. It is a potent inhibitor of the enzyme leukotriene A4 hydrolase (LTA4H), which catalyzes the rate-limiting step in the formation of leukotriene B4 (LTB4), a potent chemoattractant and activator of inflammatory immune cells including neutrophils.
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体内实验——
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同义词CTX-4430 | EP-501
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通路Others
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靶点Other Targets
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受体LTB4
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研究领域Other Indications
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适应症Fibrosis
化学信息
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CAS Number943764-99-6
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分子量481.5424
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分子式C29H27N3O4
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纯度>98% (HPLC)
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溶解度10 mM in DMSO; Methanol: ≥ 32 mg/mL
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SMILESO=C(O)C1=CC=C(CN2[C@](C3)([H])CN(CC4=CC=C(OC5=CC=C(C6=NC=CO6)C=C5)C=C4)[C@]3([H])C2)C=C1
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化学全称Benzoic acid, 4-[[(1S,4S)-5-[[4-[4-(2-oxazolyl)phenoxy]phenyl]methyl]-2,5-diazabicyclo[2.2.1]hept-2-yl]methyl]-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
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4-N-Nonyloxyphenol
4-N-Nonyloxyphenol (4-nonoxyphenol), a heterogeneous photosensitizer based on kaolinite nanotubes, is a widely used pesticide and endocrine disruptor for the photodegradation of phenol-based pesticides.
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2-Hydroxychalcone B
2'-Hydroxychalcone is a drug synthesis intermediate for the synthesis of flavonoids. 2'-Hydroxychalcone loaded in nanoemulsion showed fungicidal activity against Coccidioides parapsilosis in Danio rerio model.2'-Hydroxychalcone induced cytotoxicity through oxidative stress in lipid-loaded Hepg2 cells.2'-Hydroxychalcone inhibited the induction of ICAM-1, VCAM-α, tumor necrosis factor-α, and tumor necrosis factor-alpha as determined by reverse transcription-polymerase chain reaction determined by tumor necrosis factor-alpha induces steady-state transcript levels of ICAM-1, VCAM-1, and E-selectin, and therefore may interfere with the transcription of their genes.
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ADWX 1
Potent and selective KV1.3 channel blocker (IC50 values are 0.0019 and 0.65 nM for KV1.3 and KV1.1, respectively). Inhibits CD4+ CCR7- T cell activation. Ameliorates rat experimental autoimmune encephalomyelitis, in a model for multiple sclerosis.
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