KU-0063794

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种有效、特异性、细胞渗透性的 mTOR 抑制剂，对 mTORC1 和 mTORC2 的 IC50 均为 10 nM。

A potent, specific, cell permeant inhibitor of mTOR with IC50 of 10 nM for both mTORC1 and mTORC2; displays no activity against 76 other protein kinases or seven lipid kinases, including class 1 PI3Ks (>1,000-fold); suppresses activation and hydrophobic motif phosphorylation of Akt, S6K and SGK, but not RSK, also inhibits phosphorylation of the T-loop Thr308 of Akt, induces complete dephosphorylation of 4E-BP1 in HEK-293 cells; suppresses cell growth and induces G1-cell cycle arrest in both wild-type and mLST8 deficient MEFs.

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KU 0063794 | KU0063794

PI3K/Akt/mTOR signaling

mTOR

mTORC1|mTORC2

Cancer

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938440-64-3

465.5447

C25H31N5O4

>98% (HPLC)

10 mM in DMSO

OCC1=CC(C2=NC3=NC(N4C[C@@H](C)O[C@@H](C)C4)=NC(N5CCOCC5)=C3C=C2)=CC=C1OC

Benzenemethanol, 5-[2-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxy-, rel-

(-20℃)

With Ice Pack

≥ 2 years