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PPQ-102
CAS No. 931706-15-9
PPQ-102 ( CFTR Inhibitor IV | Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor IV )
产品货号. M16668 CAS No. 931706-15-9
PPQ-102 是一种有效的 CFTR 抑制剂，可以完全抑制 CFTR 氯电流，IC 50 约为 90 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥430 | 有现货 |
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| 5MG | ￥710 | 有现货 |
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| 10MG | ￥1216 | 有现货 |
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| 25MG | ￥2297 | 有现货 |
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| 50MG | ￥3460 | 有现货 |
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| 100MG | ￥4725 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥781 | 有现货 |
|
生物学信息
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产品名称PPQ-102
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述PPQ-102 是一种有效的 CFTR 抑制剂，可以完全抑制 CFTR 氯电流，IC 50 约为 90 nM。
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产品描述PPQ-102 is a potent CFTR inhibitor which can completely inhibited CFTR chloride current with IC 50approximately 90 nM.
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体外实验Cell Viability Assay Cell Line:E13.5 embryonic kidneys (embryonic kidney organ culture model of PKD)Concentration:0, 0.5, 5 μM Incubation Time:3 or 4 days Result:Remarkablyreduced the number and size of renal cysts formed in the 8-Br-cAMP-containing medium (showed ～60% inhibition of cyst formation at 0.5 μM, near complete absence of cysts at 2.5 and 5 μM).Remarkable reduced cyst size over 1 and 2 days in the 8-Br-cAMP-containing medium.
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体内实验——
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同义词CFTR Inhibitor IV | Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor IV
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通路Apoptosis
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靶点CFTR
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受体CFTR
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研究领域Other Indications
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适应症——
化学信息
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CAS Number931706-15-9
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分子量438.48
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分子式C26H22N4O3
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纯度>98% (HPLC)
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溶解度DMSO: 5 mg/mL
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SMILESO=C1N(C)C(C(C(N1C)=O)=C2C3=CC=CC=C3)=C4N2C5=C(C=CC=C5)NC4C6=CC=C(C)O6
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化学全称7,9-dimethyl-6-(5-methylfuran-2-yl)-11-phenyl-5,6-dihydropyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(7H,9H)-dione
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Tradtrantip L, et al. J Med Chem. 2009 Oct 22;52(20):6447-55.
