MDL-28170

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Calpain Inhibitor III 是一种有效的细胞渗透性钙蛋白酶 I 和 II 抑制剂 (Ki = 8 nM)。Calpain Inhibitor III（也参考 CAS 88191-84-8）可控制钙蛋白酶的生物活性。

Calpain Inhibitor III is a potent, cell-permeable inhibitor of calpain I and II (Ki = 8 nM)., The Calpain Inhibitor III, also referenced under CAS 88191-84-8, controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MDL-28170 significantly and time-dependently improves the recovery of synaptic responses in hippocampal slices following prolonged, moderate hypoxia without hypoxic depolarization.MDL-28170 dose-dependently inhibits brain cysteine proteinase activity (in vitro Ki= 0.01 μM).

Treatment with MDL-28170 (50 mg/kg, i.p.) completely prevents the striatal damage in four animals in each of the two treatment groups. The numbers of necrotic neurons are reduced by 85% and 68% in animals in which MDL-28170 injections are initiated at 0.5 and 3 h of recirculation, respectively.MDL-28170 (30 mg/kg, i.p.) reduces the functional and structural deterioration of corpus callosum following fluid percussion injury.MDL-28170 (10 mg/kg, i.p.) significantly improves nerve function parameters in diabetic rats. MDL-28170 (3 and 10 mg/kg, i.p.) improves nociceptive behavior in diabetic rats.

MDL 28170

Others

Other Targets

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Infection

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88191-84-8

382.46

C22H26N2O4

>98% (HPLC)

N/A

CC(C)C(C(=O)N[C@@H](CC1=CC=CC=C1)C=O)NC(=O)OCC2=CC=CC=C2

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(-20℃)

With Ice Pack

≥ 2 years