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Foxy-5
CAS No. 881188-51-8
Foxy-5 ( formyl-Met-Asp-Gly-Cys-Glu-Leu | Foxy5 )
产品货号. M16389 CAS No. 881188-51-8
Foxy-5是一种新型的Wnt-5A模拟六肽，通过靶向细胞运动来抑制体内乳腺癌转移。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Foxy-5
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Foxy-5是一种新型的Wnt-5A模拟六肽，通过靶向细胞运动来抑制体内乳腺癌转移。
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产品描述Foxy-5 is a novel Wnt-5A mimicking hexapeptide that inhibits breast cancer metastasis in vivo by targeting cell motility; also significantly inhibits the initial metastatic dissemination of prostate cancer cells to regional and distal lymph nodes, specifically targets invasion without affecting apoptosis or viability of WNT5A-low prostate cancer cells. Breast Cancer Phase 1 Clinical.
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体外实验——
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体内实验Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model.Foxy-5 reduces the number of colonic cancer stem cells in a xenograft mouse model of human colonic cancer.
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同义词formyl-Met-Asp-Gly-Cys-Glu-Leu | Foxy5
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通路Wnt/Notch/Hedgehog
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靶点Wnt/beta/catenin
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受体Wnt/beta/catenin
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研究领域Cancer
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适应症Breast Cancer
化学信息
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CAS Number881188-51-8
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分子量694.77
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分子式C26H42N6O12S2
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纯度>98% (HPLC)
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溶解度——
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SMILESCC(C)C[C@@H](C(O)=O)NC([C@H](CCC(O)=O)NC([C@H](CS)NC(CNC([C@H](CC(O)=O)NC([C@H](CCSC)NC=O)=O)=O)=O)=O)=O
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化学全称(2S,5S,8R,14S)-5-(2-carboxyethyl)-14-((S)-2-formamido-4-(methylthio)butanamido)-2-isobutyl-8-(mercaptomethyl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazahexadecanedioic acid
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. S?fholm A, et al. Clin Cancer Res. 2008 Oct 15;14(20):6556-63.
2. Ford CE, et al. Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3919-24.
3. Canesin G, et al. PLoS One. 2017 Sep 8;12(9):e0184418.
产品手册
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