Tpl2-IN-2p

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种有效、选择性、可逆且 ATP 竞争性的 Tpl2 激酶抑制剂，IC50 为 50 nM。

A potent, selective, reversible and ATP-competitive inhibitor of Tpl2 kinase with IC50 of 50 nM; dispalys significant selectivity over other related kinases (IC50= 5, >40, 110, 180, >400 and >400 uM for EGFR, MEK, MK2, p38, Src, and PKC, respectively); inhibits LPS-induced TNF-α production both from primary human monocytes and in whole blood with IC50 of 0.7 and 8.5 uM, respectively.

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c-Cot Kinase Inhibitor | MAP3K8 Kinase Inhibitor | Tumor Progression Locus 2 Kinase Inhibitor

MAPK/ERK Signaling

MEK

MEK

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871307-18-5

404.83

C21H14ClFN6

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (247.02 mM)

N#CC1=C(NC2=CC=C(F)C(Cl)=C2)C3=CC(NCC4=CC=CN=C4)=NC=C3N=C1

4-((3-chloro-4-fluorophenyl)amino)-6-((pyridin-3-ylmethyl)amino)-1,7-naphthyridine-3-carbonitrile

(-20℃)

With Ice Pack

≥ 2 years