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TRC-051384
CAS No. 867164-40-7
TRC-051384 ( TRC051384 )
产品货号. M16303 CAS No. 867164-40-7
一种有效的热休克蛋白 70 (HSP70) 诱导剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥708 | 有现货 |
|
| 10MG | ￥1102 | 有现货 |
|
| 25MG | ￥2074 | 有现货 |
|
| 50MG | ￥2930 | 有现货 |
|
| 100MG | ￥4104 | 有现货 |
|
| 200MG | ￥5751 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥724 | 有现货 |
|
生物学信息
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产品名称TRC-051384
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述一种有效的热休克蛋白 70 (HSP70) 诱导剂。
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产品描述A potent heat shock protein 70 (HSP70) inducer, involves HSF1 activation; significantly reduces stroke associated neuronal injury and disability in a rat model of transient ischemic stroke; delays thrombus formation without increased bleeding risk in mice.
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体外实验TRC051384, dose dependently induces HSP70B mRNA by several hundred folds in both HeLa and rat primary mixed neurons. Treatment with TRC051384 results in significant dose-dependent increase in HSF1 transcriptional activity and recovery of luciferase activity. TRC051384 results in 60% inhibition at 6.25 μM and 90% inhibition at 12.5 μM of LPS-induced TNF-α expression in differentiated THP-1 cell line.
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体内实验Treatment with TRC051384 significantly reduces stroke associated neuronal injury (87% reduction in area of penumbra recruited to infarct, and 25% reduction in brain edema) and disability in a rat model of transient ischemic stroke even when administered 8 hours post onset of ischemia. Significant improvement in survival (50% by day2 and 67.3% by day 7) is observed with TRC051384 treatment initiated at 4 hours after ischemia onset. Induction of HSP70 by TRC051384 involves HSF1 activation and results in elevated chaperone and anti-inflammatory activity.
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同义词TRC051384
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通路Cytoskeleton/Cell Adhesion Molecules
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靶点HSP
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受体HSP70
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研究领域Metabolic Disease
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适应症——
化学信息
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CAS Number867164-40-7
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分子量465.54
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分子式C25H31N5O4
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纯度>98% (HPLC)
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溶解度DMSO: ≥100 mg/mL
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SMILESO=C(NC1=CC=C(C(/C=C/C2=NC(N3CCOCC3)=CC=C2)=O)C=C1)NCCN4CCOCC4
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化学全称Urea, N-[2-(4-morpholinyl)ethyl]-N'-[4-[3-[6-(4-morpholinyl)-2-pyridinyl]-1-oxo-2-propen-1-yl]phenyl]-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Mohanan A, et al. Neuropharmacology. 2011 May;60(6):991-9.
2. Allende M, et al. Cardiovasc Res. 2016 Jun 1;110(3):309-18.
产品手册
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