MK-8591

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

MK-8591（Islatravir、MK8591、EFdA）是一种核苷类似物，对野生型和耐药 HIV 具有显着的功效。

MK-8591 (Islatravir, MK8591, EFdA) is a nucleoside analog that exhibits remarkable potency against wild-type and drug-resistant HIVs, inhibits HIV-1 reverse transcriptase with multiple mechanisms; also retains potent activity against multinucleoside-resistant HIV-2 mutants (EC50<11 nM).HIV Infection Phase 2 Clinical.

Islatravir (MK-8591) (4'Ed2FA) is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC50s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively.

——

Islatravir | MK8591 | EFdA

Microbiology/Virology

HIV

HIV

Infection

HIV Infection

865363-93-5

293.25

C12H12FN5O3

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (341.01 mM)

NC1=C(N=CN2[C@H]3C[C@@H]([C@@](O3)(C#C)CO)O)C2=NC(F)=N1

(2R,3S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-2-ethynyl-2-(hydroxymethyl)tetrahydrofuran-3-ol

(-20℃)

With Ice Pack

≥ 2 years