Dibucaine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

地布卡因是一种酰胺型局部麻醉剂，目前通常用于表面麻醉。

Dibucaine is a local anesthetic of the amide type now generally used for surface anesthesia.(In Vitro):Dibucaine (Cinchocaine) reduces the degradation of BSA-gold complex in the reservosomes, which was not caused either by an inhibition of the whole proteolytic activity of the parasite or by a reduction on the expression levels of cruzipain. Dibucaine, a quaternary ammonium compound, inhibited SChE to a minimum within 2 min in a reversible manner. The inhibition was very potent. It had an IC(50) of 5.3 microM with BuTch or 3.8 microM with AcTch. The inhibition was competitive with respect to BuTch with a K(i) of 1.3 microM and a linear-mixed type (competitive/noncompetitive) with respect to AcTch with inhibition constants, K(i) and K(I) of 0.66 and 2.5 microM, respectively. Dibucaine possesses a butoxy side chain that is similar to the butryl group of BuTch and longer by an ethylene group from AcTch.

Dibucaine (Cinchocaine) reduces the degradation of BSA-gold complex in the reservosomes, which was not caused either by an inhibition of the whole proteolytic activity of the parasite or by a reduction on the expression levels of cruzipain.Dibucaine, a quaternary ammonium compound, inhibited SChE to a minimum within 2 min in a reversible manner. The inhibition was very potent. It had an IC(50) of 5.3 microM with BuTch or 3.8 microM with AcTch. The inhibition was competitive with respect to BuTch with a K(i) of 1.3 microM and a linear-mixed type (competitive/noncompetitive) with respect to AcTch with inhibition constants, K(i) and K(I) of 0.66 and 2.5 microM, respectively. Dibucaine possesses a butoxy side chain that is similar to the butryl group of BuTch and longer by an ethylene group from AcTch.

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NSC 159055

Endocrinology/Hormones

AChR

AChR| CAM| Sodium Channel

Neurological Disease

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85-79-0

343.46

C20H29N3O2

>98% (HPLC)

Water: 42 mg/L (at 21 °C)

CCCCOC1=NC2=CC=CC=C2C(=C1)C(=O)NCCN(CC)CC

2-butoxy-N-[2-(diethylamino)ethyl]quinoline-4-carboxamide

(-20℃)

With Ice Pack

≥ 2 years