AKT Kinase Inhibitor ( —— )

产品货号. M16130 CAS No. 842148-40-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

AKT Kinase Inhibitor
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Akt 激酶抑制剂。
产品描述

An Akt kinase inhibitor.
体外实验

The effect of selective inhibition of Akt in proliferating cells expressing Trop-2 is studied.Akt inhibition, either by silencing or with specific drugs, induces a marked decrease in cell proliferation in cells expressing Trop-2, in a dose-dependent fashion.
体内实验

Trop-2 expressing tumors subcutaneously injected in animal models show a striking reduction of growth following treatment with specific drugs that inhibit Akt activity. Therefore Akt has a central functional role in mediating the Trop-2-dependent growth stimulus.
同义词

——
通路

Cytoskeleton/Cell Adhesion Molecules
靶点

Akt
受体

Akt
研究领域

Cancer
适应症

——

CAS Number

842148-40-7
分子量

357.3672
分子式

C16H19N7O3
纯度

>98% (HPLC)
溶解度

10 mM in DMSO
SMILES

CCN1C2=C(C(=NC=C2OCCCN)C#CCO)N=C1C3=NON=C3N
化学全称

2-Propyn-1-ol, 3-[2-(4-amino-1,2,5-oxadiazol-3-yl)-7-(3-aminopropoxy)-1-ethyl-1H-imidazo[4,5-c]pyridin-4-yl]-