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JNJ-26993135
CAS No. 841202-16-2
JNJ-26993135 ( JNJ26993135 )
产品货号. M16124 CAS No. 841202-16-2
JNJ-26993135 是一种有效的选择性白三烯 A4 水解酶 (LTA4H) 抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 25MG | ￥9858 | 有现货 |
|
| 50MG | ￥12834 | 有现货 |
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| 100MG | ￥15750 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称JNJ-26993135
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述JNJ-26993135 是一种有效的选择性白三烯 A4 水解酶 (LTA4H) 抑制剂。
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产品描述JNJ-26993135 is a potent, selective leukotriene A4 hydrolase (LTA4H) inhibitor, inhibits both the epoxide hydrolase and aminopeptidase activities of recombinant human LTA4H with IC50 of 10 nM; has no significant effects on LTC4, lipoxin A4, or PGE2 production; dose-dependently inhibits ex vivo LTB(4) production in blood (IC50=339 nM), in parallel with dose-dependent inhibition of neutrophil influx (ED50, 1-3 mg/kg) and ear edema in murine model of arachidonic acid-induced ear inflammation; selectively inhibited LTB(4) production, without affecting cysteinyl leukotriene production.
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体外实验——
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体内实验——
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同义词JNJ26993135
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通路Metabolic Enzyme/Protease
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靶点Aminopeptidase
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受体Aminopeptidase
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研究领域——
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适应症——
化学信息
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CAS Number841202-16-2
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分子量368.451
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分子式C20H20N2O3S
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C(C1CCN(CC2=CC=C(OC3=NC4=CC=CC=C4S3)C=C2)CC1)O
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化学全称1-[4-(benzothiazol-2-yloxy)-benzyl]-piperidine-4-carboxylic acid
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Rao NL, et al. J Pharmacol Exp Ther. 2007 Jun;321(3):1154-60.
2. Whittle BJ, et al. Br J Pharmacol. 2008 Mar;153(5):983-91.
