Lamotrigine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

拉莫三嗪是一种抗惊厥化合物，用于治疗癫痫和双相情感障碍。

Lamotrigine is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. For epilepsy it is used to treat partial seizures, primary and secondary tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome. Lamotrigine also acts as a mood stabilizer. It is the first medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of bipolar type I. Chemically unrelated to other anticonvulsants, lamotrigine has relatively few side-effects and does not require blood monitoring. (In Vitro):Lamotrigine inhibits Veratrine evoked release of glutamate and aspartate with ED50 values of 21 μM for both amino acids, but Lamotrigine is less potent in the inhibition of GABA release (ED50=44 μM. At concentrations up to 300 μM, LTG has no effect on patassium-evoked amino acid.Lamotrigine is some five times less potent in the inhibition of Veratrine-evoked [3H]acetylcholine release (ED50=100 μM) than in glutamate or aspartate release.(In Vivo):Lamotrigine (IP, 30 min before pentylenetetrazol; 10 mg/kg, 15 mg/kg or 20 mg/kg) decreases the seizure intensity at the higher doses, it increases the latency to the first pentylenetetrazol-induced seizure in all studied doses compared with the controls.

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Animal Model:White male mice weighing 25-30 g Dosage:10 mg/kg, 15 mg/kg or 20 mg/kg Administration:Intraperitoneally 30 min before pentylenetetrazol Result:Had an anti-convulsive effect in seizure models, suppressing seizure intensity and influencing the latency to the first seizure.

BW 430C | Epilepax | Lamictal | LTG

Endocrinology/Hormones

5-HT Receptor

5-HT (human platelets)| 5-HT (rat brain synaptosomes)

Neurological Disease

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84057-84-1

256.09

C9H7Cl2N5

>98% (HPLC)

Ethanol: 3 mg/mL (11.71 mM); DMSO: 10 mg/mL (39.04 mM)

NC1=NC(N)=C(C2=CC=CC(Cl)=C2Cl)N=N1

6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine

(-20℃)

With Ice Pack

≥ 2 years