Cetirizine dihydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

第二代抗组胺药，作为选择性 H1 受体拮抗剂。

A second-generation antihistamine that acts as a selective H1 receptor antagonist; used in the treatment of allergies.Allergy Approved(In Vitro):Cetirizine (>5 μM) at higher concentrations can reduce the release of GM-CSF and IL-8 from A549 cells stimulated with IL-1β. Cetirizine exerts anti-inflammatory effects beyond histamine H1-receptor antagonist.(In Vivo):Cetirizine (20 mg/kg, mice, orally) exerts its anti-inflammatory effects by inhibiting MIF as well as IL-8 production in mice immunized and challenged with ragweed pollen.

Cetirizine (>5 μM) at higher concentrations can reduce the release of GM-CSF and IL-8 from A549 cells stimulated with IL-1β. Cetirizine exerts anti-inflammatory effects beyond histamine H1-receptor antagonist. Cell Viability AssayCell Line:Human airway epithelial cell line A549.Concentration:0-10 μM.Incubation Time:24 h.Result:The survival of A549 cells incubated with various concentrations of cetirizine (0.1, 1, 2.5, 5, and 10 μM) for 24 hours were all higher than 90% when comparing with the control group by MTT test.Cetirizine, 5 and 10 μM, suppressed GM-CSF release by 70.71 and 61.55%, respectively.Preincubation with cetirizine, 10 μM, suppressed the IL-8 secretion by 75.04%.

Cetirizine (20 mg/kg, mice, orally) exerts its anti-inflammatory effects by inhibiting MIF as well as IL-8 production in mice immunized and challenged with ragweed pollen. Animal Model:Male 8-week-old BALB/c mice (25-30 g) immunized and challenged with ragweed pollen.Dosage:2 or 20 mg/kg.Administration:Orally, diluted in sterile water on days 18, 19, and 20.

P-071

GPCR/G Protein

Histamine Receptor

H1receptor

Inflammation/Immunology

Allergy

83881-52-1

461.8097

C21H27Cl3N2O3

>98% (HPLC)

10 mM in DMSO

Cl.OC(=O)COCCN1CCN(CC1)C(C1=CC=CC=C1)C1=CC=C(Cl)C=C1

Acetic acid, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, hydrochloride (1:2)

(-20℃)

With Ice Pack

≥ 2 years