Mecamylamine hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种烟碱拮抗剂，可很好地从胃肠道吸收并穿过血脑屏障。

A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.

Western Blot Analysis Cell Line:SCG neurons Concentration:10 μM Incubation Time:48 h Result:Reduced the nicotine-facilitated increase in ERK1/2.

Animal Model:Choroidal neovascularization (CNV) mice model Dosage:50 mg/kg/day, 2 days Administration:Subcutaneous pumps implanted beneath the skin of the back, 200 μL and mean pumping rate of 0.5 μL/h. Result: Suppressed the development of CNV at Bruch’s membrane rupture sites in the absence of nicotine.Animal Model:C57BL/6J mice Dosage:0.5-1 mg/kg Administration:Intraperitoneal injection Result:Had no effect in β2 knockout mice and α7 knockout mice, but decreased immobility time in wildtype littermates in the FST.

Inversine

Endocrinology/Hormones

AChR

nAChR

——

——

826-39-1

203.75

C11H22ClN

>98% (HPLC)

Soluble in DMSO

CC1(C)C(NC)(C)C2CCC1C2.[H]Cl

N,2,3,3-tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride

(-20℃)

With Ice Pack

≥ 2 years