Lidocaine hydrochloride ( —— )

产品货号. M15821 CAS No. 73-78-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Lidocaine hydrochloride
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

盐酸利多卡因盐是一种酰胺局部麻醉剂，在体外和体内具有抗炎特性。
产品描述

Lidocaine HCl salt, an amide local anesthetic, has anti-inflammatory properties in vitro and in vivo, possibly due to an attenuation of pro-inflammatory cytokines, intracellular adhesion molecule-1 (ICAM-1), and reduction of neutrophils influx.
体外实验

Cell Proliferation Assay Cell Line:The human gastric cancer cell line MKN45 Concentration:10?nM Incubation Time:48 hours Result:Decreased significantly cell proliferation.Cell Viability Assay Cell Line:The human gastric cancer cell line MKN45 Concentration:1, 5 and 10?nM Incubation Time:24, 48, 72 hours Result:Inhibited MKN45 cell viability.Apoptosis Analysis Cell Line:The human gastric cancer cell line MKN45 Concentration:10?nM Incubation Time:48 hours Result:Increased significantly the apoptotic cell rate.Western Blot Analysis Cell Line:The human gastric cancer cell line MKN45 Concentration:10?nM Incubation Time:48 hours Result:Down-regulated Cyclin D1 and up-regulated p21 expression significantly.
体内实验

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同义词

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通路

Membrane Transporter/Ion Channel
靶点

Sodium Channel
受体

Sodium Channel
研究领域

Inflammation/Immunology
适应症

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1.Moch CInt J Pharm. 2014 Apr 10;464(1-2):91-103.

计算器

产品手册

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