BMS-707035

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

BMS-707035 是一种有效、特异性和可逆的 HIV-1 整合酶 (IN) 抑制剂，可阻断 HIV IN 链转移活性，IC50 为 15 nM。

BMS-707035 is a potent, specific, and reversible HIV-I integrase (IN) inhibitor that blocks HIV IN strand transfer activity with IC50 of 15 nM.HIV Infection Phase 2 Discontinued.

BMS-707035 has antiviral activity with EC50 values of 2 nM and 17 nM in the presence of 10% FBS and 15 mg/mL human serum albumin, respectively.BMS-707035 has high plasma protein binding and not overtly cytotoxicy to several cell lines, with CC50 value of ≥45 μM.BMS-707035 has a relatively weak CYP inhibiton with IC50 value of ≥40 μM.

BMS-707035 has a low clearance effect in the rat, dog and monkey with moderate to long elimination half-lives in all species.Pharmacokinetic Parameters of BMS-707035 in rat, dog and monkey (IV).

BMS 707035 | BMS707035

Microbiology/Virology

HIV

HIV-Iintegrase

Infection

HIV Infection

729607-74-3

410.42

C17H19FN4O5S

>98% (HPLC)

10 mM in DMSO

Cn1c(=O)c(c(nc1N2CCCCS2(=O)=O)C(=O)NCc3ccc(cc3)F)O

4-Pyrimidinecarboxamide, N-[(4-fluorophenyl)methyl]-1,6-dihydro-5-hydroxy-1-methyl-6-oxo-2-(tetrahydro-1,1-dioxido-2H-1,2-thiazin-2-yl)-

(-20℃)

With Ice Pack

≥ 2 years