Psoralen

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

补骨脂素在 DNA 突变和修复机制的研究中用作光化学探针。引起人体光敏化。

Psoralen is used as photochemical probe in studies of DNA mutation and repair mechanisms. Causes photosensitization in human.(In Vitro):Psoralen (10-500 μM; 24-48 hours) inhibits cell viability in a concentration- and time-dependent manner in L02 and HepG2 cells. In L02 cells, Psoralen at 400 μM does not significantly change extracellular LDH levels, and 400 μM or 450 μM psoralen inhibits 50–60% of cell viability.Psoralen (150-450 μM; 24 hours) induces significant S-phase arrest in L02 cells in time- and dose-dependent manners, but it does not exhibits significant change in the cycle distribution of HepG2 cells.(In Vivo):Psoralen (oral gavage; 17.5 mg/kg; 6 weeks) reduces the number of metastatic lesions and the rate of bone metastasis by 20% compared to vehicle-treated mice. It also reduces tumor infiltration and decreases the percentage of tumor cells in metastatic lesions by ~40% compared to vehicle in mice.

Cell Proliferation Assay Cell Line:L02 and?HepG2 cells Concentration:10 μM, 50 μM,100 μM, 200 μM, 300 μM,400 μM,450 μM,500 μM Incubation Time:24 or 48 hours Result:Inhibited the viability of L02 and HepG2 cells mainly by suppressing cell proliferation rather than causing cell death. Cell Cycle Analysis Cell Line:L02 and?HepG2 cells Concentration:150 μM; 300 μM; 450 μM Incubation Time:24 or 48 hours Result:Induced cell S-phase arrest instead of causing cell apoptosis or death.

Animal Model:Female nude (BALB/c nu/nu) mice Dosage:17.5 mg/kg Administration:Oral gavage; 17.5 mg/kg; 6 weeks Result:Inhibited metastasis of breast cancer to bone in vivo.

Ficusin | Furocoumarin | NSC 404562

Others

Other Targets

Others

Cancer

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66-97-7

186.17

C11H6O3

>98% (HPLC)

DMSO: 10 mM

O=C1OC2=CC3=C(C=CO3)C=C2C=C1

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(-20℃)

With Ice Pack

≥ 2 years