Nanchangmycin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种从南昌链霉菌 NS3226 中分离出来的聚醚离子载体抗生素，具有抗菌和抗病毒特性。

A polyether ionophore antibiotic isolated from Streptomyces nanchangensis NS3226 that shows antibacterial and antiviral properties; A potent inhibitor of Zika virus entry, also is active against other medically relevant viruses, including West Nile, dengue, and chikungunya viruses.

Nanchangmycin can be used as a growth promotant in poultry and to cure coccidiosis in chickens. Nanchangmycin is active against drug resistant strains of malaria. Nanchangmycin as a potent inhibitor of Zika virus (ZIKV) entry across all cell types tested including physiologically relevant primary cells. Nanchangmycin potently reduces infection of all three strains of ZIKV across all three cell types. The IC50s for infection are between 0.1 and 0.4 μM while Nanchangmycin has low toxicity in these ranges. In addition, DENV is inhibited by Nanchangmycin across cell types.

——

Nanchangmycin A

GPCR/G Protein

Antibacterial

Others

Other Indications

——

65101-87-3

889.0956

C47H77NaO14

>98% (HPLC)

DMSO: ≥ 26 mg/mL

C[C@H]([C@@H](O1)[C@H](C)[C@@H](O)C[C@@]21CC[C@@](C)([C@@H](C[C@H](OC3O[C@H](C)[C@@H](OC)CC3)[C@H]4C)O[C@]54[C@@H](C)C[C@H]([C@H]6O[C@](CO)(O)[C@H](C)C[C@@H]6C)O5)O2)/C=C(C)/C([C@H](C)C[C@H](C)C([O-])=O)=O.[Na+]

6-Nonenoic acid, 8-[(2S,2'R,4'S,5R,5'S,7R,7'R,8R,9S,9'S,10'R)-9-hydroxy-2,4',8,10'-tetramethyl-2'-[(2S,3S,5R,6R)-tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-9'-[[(2S,5S,6R)-tetrahydro-5-methoxy-6-methyl-2H-pyran-2-yl]oxy][2,7'-bi-1,

(-20℃)

With Ice Pack

≥ 2 years