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IMB-301
CAS No. 64009-84-3
IMB-301 ( IMB301 | NSC 301209 )
产品货号. M15432 CAS No. 64009-84-3
IMB-301 (NSC 301209) 是一种小分子抑制剂，针对 HIV-1 Vif/hA3G 复合物的结合界面。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥938 | 有现货 |
|
| 10MG | ￥1549 | 有现货 |
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| 25MG | ￥2492 | 有现货 |
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| 50MG | ￥3497 | 有现货 |
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| 100MG | ￥4572 | 有现货 |
|
| 200MG | ￥6138 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥812 | 有现货 |
|
生物学信息
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产品名称IMB-301
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述IMB-301 (NSC 301209) 是一种小分子抑制剂，针对 HIV-1 Vif/hA3G 复合物的结合界面。
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产品描述IMB-301 (NSC 301209) is a small molecule inhibitor that target the binding interface of the HIV-1 Vif/hA3G complex, inhibits the replication of HIV-1 in H9 cells (IC50=8.63 uM); restores hA3G expression in the presence of Vif through disruption of the Vif-hA3G interaction, significantly increases the amount of hA3G-HA in the virions; directly binds to hA3G with of 15.6 uM.
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体外实验IMB-301 is able to increase virion encapsidation of hA3G via its ability to impair the degradation of hA3Gby Vif, which results in hA3G-dependent anti-HIV activity. IMB-301 binds to hA3G, restores hA3G expression in the presence of Vif, and inhibits the replication of HIV-1 in a hA3G-dependent manner.
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体内实验——
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同义词IMB301 | NSC 301209
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通路Microbiology/Virology
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靶点HIV
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受体HIV
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研究领域——
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适应症——
化学信息
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CAS Number64009-84-3
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分子量379.256
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分子式C19H17Cl2FN2O
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 100 mg/mL (263.67 mM)
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SMILESC1=CC(=CC=C1OCCC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)F
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化学全称1-(2-(2,4-dichlorophenyl)-4-(4-fluorophenoxy)butyl)-1H-imidazole
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Ma L, et al. Sci Rep. 2018 May 23;8(1):8067.
产品手册
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