Amodiaquine hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种具有抗炎特性的 4-氨基喹啉化合物。

A 4-aminoquinoline compound with anti-inflammatory properties. (In Vitro):Amodiaquine (10-20 μM; 4 hours) treatment suppresses LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner.Amodiaquine (5 μM; 24 hours) significantly inhibits neurotoxin (6-OHDA-induced cell death in primary dopamine cells as examined by the number of TH+ neurons and dopamine uptake. The neuroprotective effect of Amodiaquine is also observed in rat PC12 cells.(In Vivo):Amodiaquine (40 mg/kg; intraperitoneal injection; daily; for 3 days; male ICR mice) treatment diminishes perihematomal activation of microglia/macrophages and astrocytes. Amodiaquine also suppresses ICH-induced mRNA expression of IL-1β, CCL2 and CXCL2, and ameliorated motor dysfunction of mice.

Amodiaquine (10-20 μM; 4 hours) treatment suppresses LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner.Amodiaquine (5 μM; 24 hours) significantly inhibits neurotoxin (6-OHDA-induced cell death in primary dopamine cells as examined by the number of TH+ neurons and dopamine uptake. The neuroprotective effect of Amodiaquine is also observed in rat PC12 cells. RT-PCR Cell Line:Primary microglia Concentration:10 μM, 15 μM, 20 μM Incubation Time:4 hours Result:Suppressed LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner.

Amodiaquine (40 mg/kg; intraperitoneal injection; daily; for 3 days; male ICR mice) treatment diminishes perihematomal activation of microglia/macrophages and astrocytes. Amodiaquine also suppresses ICH-induced mRNA expression of IL-1β, CCL2 and CXCL2, and ameliorated motor dysfunction of mice. Animal Model:Male ICR mice (8-10?weeks of age) induced ntracerebral hemorrhage (ICH) Dosage:40 mg/kg Administration:Intraperitoneal injection; daily; for 3 days Result:Diminished perihematomal activation of microglia/macrophages and astrocytes.

——

GPCR/G Protein

Histamine Receptor

histamine N-methyl transferase

Infection

——

6398-98-7

464.82

C20H28Cl3N3O3

>98% (HPLC)

Water: 10 mM

O.O.Cl.Cl.CCN(CC)CC1=C(O)C=CC(NC2=C3C=CC(Cl)=CC3=NC=C2)=C1

——

(-20℃)

With Ice Pack

≥ 2 years