Berberine hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种来自小檗科Hydrastis canadensis L.的生物碱。它也存在于许多其他植物中。

An alkaloid from Hydrastis canadensis L., Berberidaceae. It is also found in many other plants. It is relatively toxic parenterally, but has been used orally for various parasitic and fungal infections and as antidiarrheal.

Cell Proliferation Assay Cell Line:Four colorectal carcinoma cell lines LoVo, HCT116, SW480, and HT-29 Concentration:1.25, 2.5, 5, 10, 20, 40, 80, and 160 μM Incubation Time:72 hours Result:Inhibited the proliferation of four cell lines. The IC50 ranged from 40.8±4.1 μM (LoVo) to 98.6±2.9 μM (HCT116).Cell Proliferation Assay Cell Line:Colorectal carcinoma cell lines LoVo Concentration:1.25, 2.5, 5, 10, 20, 40, 80, and 160 μM Incubation Time:24, 48, 72 hours Result:Induced a time- and dose-dependent inhibition of cell growth. By 72 h, 160.0 μM induced 71.1±1.9 % growth inhibitions in LoVo cells.Cell Cycle Analysis Cell Line:LoVo cells Concentration:0, 10, 20, 40, or 80 μM Incubation Time:24 hours Result:Exposure to 40.0 μM induced G2/M-phase cell cycle arrest, an increase in the G2/M-phase population and a progressive decline in the G1 population.Western Blot AnalysisCell Line:LoVo cellsConcentration:10, 20, 40, or 80 μM Incubation Time:24 hours Result:Suppressed cyclin B1, cdc2 and cdc25c protein expression.

Animal Model:5-week-old BALB/c nu/nu mice with human colorectal adenocarcinoma LoVo xenografts Dosage:10, 30, or 50 mg/kg/day Administration:Gastrointestinal gavage; for 10 consecutive days Result:Showed inhibitory rates of 33.1 % and 45.3 % at doses of 30 and 50 mg/kg/day.

BBR | Umbellatine

Others

Other Targets

Others

Cancer

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633-65-8

371.8

C20H18ClNO4

>98% (HPLC)

DMSO: 74 mg/mL (199.02 mM)

[Cl-].COC1=C(OC)C2=C[N+]3=C(C=C2C=C1)C1=CC2=C(OCO2)C=C1CC3

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(-20℃)

With Ice Pack

≥ 2 years