Dihydroergotamine Mesylate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

二氢麦角胺甲磺酸盐是一种麦角生物碱，用于治疗偏头痛。

Dihydroergotamine mesylate is an ergot alkaloid used to treat migraines.

——

Animal Model:HepG2 cell xenografted mice Dosage:44 mg/kg plus 30 mg/kg of Sorafenib Administration:oral gavage,a total of 31 days of treatment, a gavage every day for 5 days in a row, followed by 2 days of rest. Result:Reduced the average tumor weight and tumor volumes in the combined therapy group compared with either compound alone or control group. Reduced Ki67 positive cells, reduced expression of Mcl-1, p-Mcl-1 and p-ERK.

(+)-Dihydroergotamine

Endocrinology/Hormones

5-HT Receptor

5-HT

Neurological Disease

——

6190-39-2

679.8

C34H41N5O8S

>98% (HPLC)

DMSO: 100 mM

O=C([C@@H](CN(C)[C@]1([H])C2)C[C@]1([H])C3=C4C2=CNC4=CC=C3)N[C@](C(N5[C@H]6CC7=CC=CC=C7)=O)(C)O[C@@]5(O)[C@]8([H])CCCN8C6=O.OS(=O)(C)=O

(2R,4R,7R)-N-[(1S,2S,4R,7S)-7-Benzyl-2-hydroxy-4-methyl-5,8-dioxo-3-oxa-6,9-diazatricyclo[7.3.0.02,6]dodecan-4-yl]-6-methyl-6,11-diazatetracyclo-[7.6.1.02,7.012,16]hexadeca-1(16),9,12,14-tetraene-4-carboxamide mesylate

(-20℃)

With Ice Pack

≥ 2 years