Bromhexine hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

盐酸溴己新是一种治疗咳嗽的化合物，通过溶解硬痰起作用。

Bromhexine Hydrochloride is a medication prescribed for coughs which works by dissolving hard phlegm.(In Vitro):Bromhexine hydrochloride (BHH; 250μM; 24 hours) also significantly attenuates HGF-induced invasion of LNCaP and C4-2B cells that natively express TMPRSS2.No significant toxicity is observed over a 48-hour period exposing LNCaP, DU145, PC3, or HepG2 cells to Bromhexine hydrochloride concentrations ranging from 0μM to 250μM. Bromhexine hydrochloride exposure does not induce cell death or substantially suppress the growth of DU145 cells.Bromhexine hydrochloride (20?μM; 48?h) inhibits dendritic cells infection with HIV-1.(In Vivo):Bromhexine hydrochloride (30mg/kg; ip; three times per week for 5 weeks) significantly reduces the incidence of distant metastasis to lung and liver sites from 55% in vehicle-treated animals to 20% in Wild-type C57BL/6 and TRAMP mice with PIN (prostatic intraepithelial neoplasia). The prostate glands of the mice treated with Bromhexine hydrochloride are generally substantially larger than vehicle-treated TRAMP mice.

Bromhexine hydrochloride (BHH; 250μM; 24 hours) also significantly attenuates HGF-induced invasion of LNCaP and C4-2B cells that natively express TMPRSS2.No significant toxicity is observed over a 48-hour period exposing LNCaP, DU145, PC3, or HepG2 cells to Bromhexine hydrochloride concentrations ranging from 0μM to 250μM. Bromhexine hydrochloride exposure does not induce cell death or substantially suppress the growth of DU145 cells. Bromhexine hydrochloride (20?μM; 48?h) inhibits dendritic cells infection with HIV-1.

Bromhexine hydrochloride (30mg/kg; ip; three times per week for 5 weeks) significantly reduces the incidence of distant metastasis to lung and liver sites from 55% in vehicle-treated animals to 20% in Wild-type C57BL/6 and TRAMP mice with PIN (prostatic intraepithelial neoplasia). The prostate glands of the mice treated with Bromhexine hydrochloride are generally substantially larger than vehicle-treated TRAMP mice.

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Others

Other Targets

Others

Metabolic Disease

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611-75-6

412.59

C14H21Br2ClN2

>98% (HPLC)

Ethanol: 5 mg/mL (12.11 mM); DMSO: 6 mg/mL (14.54 mM)

Cl.CN(CC1=CC(Br)=CC(Br)=C1N)C1CCCCC1

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(-20℃)

With Ice Pack

≥ 2 years