Dibucaine hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Dibucaine hydrochloride (Cinchocaine hydrochloride) 是一种钠通道抑制剂。 Dibucaine hydrochloride 是有效的 SChE 抑制剂。

A local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia.

Dibucaine hydrochloride (Cinchocaine hydrochloride) reduced the degradation of BSA-gold complex in the reservosomes, which was not caused either by an inhibition of the whole proteolytic activity of the parasite or by a reduction on the expression levels of cruzipain.Dibucaine, a quaternary ammonium compound, inhibited SChE to a minimum within 2 min in a reversible manner. The inhibition was very potent. It had an IC(50) of 5.3 microM with BuTch or 3.8 microM with AcTch. The inhibition was competitive with respect to BuTch with a K(i) of 1.3 microM and a linear-mixed type (competitive/noncompetitive) with respect to AcTch with inhibition constants, K(i) and K(I) of 0.66 and 2.5 microM, respectively. Dibucaine possesses a butoxy side chain that is similar to the butryl group of BuTch and longer by an ethylene group from AcTch.

——

Dibucaine HCl | Dibucaine Hydrochloride | Cinchocaine hydrochloride | Cincaine chloride | Cincain

Endocrinology/Hormones

AChR

AChR| Sodium Channel

Neurological Disease

——

61-12-1

379.92

C20H30ClN3O2

>98% (HPLC)

Ethanol: 76 mg/mL (200.04 mM); Water: 76 mg/mL (200.04 mM); DMSO: 76 mg/mL (200.04 mM)

O=C(C1=CC(OCCCC)=NC2=CC=CC=C12)NCCN(CC)CC.[H]Cl

2-Butoxy-N-[2-(diethylamino)ethyl]quinoline-4-carboxamide hydrochloride

(-20℃)

With Ice Pack

≥ 2 years