Haloperidol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Haloperidol 是有效的 dopamine D2 receptor 拮抗剂，为一种安定药。

Haloperidol has been found to be highlt potent neuroleptic by relieving nervous through the depression of nerve function. Besides, Haloperidol has shown about 50-fold potency than chiorpromazine, the other antipsychotic drug. Haloperidol has shown beneficial effects in the treatment of delusions and hallucinations. These effects are mainly achieved through blockage of dopamine receptors in the mesocortex and limbic system. (In Vivo):Haloperidol (1 mg) intra-arterially attenuates the dopamine-induced pancreatic secretion. Haloperidol (3 mg) completely inhibits the action of 10 μg of dopamine in the pancreas of the dogs. Haloperidol (10 mg/kg) as well as chlorpromazine (CPZ, 15 mg/kg) blocks mescaline-induced altered behavior within 7 to 10 minutes when injected into the mice 45 minutes after 50 mg/kg (2 μc) of mescaline. Haloperidol has no effect on mescaline disappearance.

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Haloperidol (1 mg) intra-arterially attenuates the dopamine-induced pancreatic secretion. Haloperidol (3 mg) completely inhibits the action of 10 μg of dopamine in the pancreas of the dogs. Haloperidol (10 mg/kg) as well as chlorpromazine (CPZ, 15 mg/kg) blocks mescaline-induced altered behavior within 7 to 10 minutes when injected into the mice 45 minutes after 50 mg/kg (2 μc) of mescaline. Haloperidol has no effect on mescaline disappearance.

McN-JR 1625 | NSC 170973 | NSC 615296 | R 1625

Endocrinology/Hormones

5-HT Receptor

5-HT| Dopamine

Neurological Disease

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52-86-8

375.87

C21H23ClFNO2

>98% (HPLC)

Ethanol: 8 mg/mL (21.28 mM); DMSO: 75 mg/mL (199.54 mM)

C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCC(=O)C3=CC=C(C=C3)F

4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one

(-20℃)

With Ice Pack

≥ 2 years