Pranoprofen

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Pranoprofen 是一种 PGE2 抑制剂，IC50 为 7.5 μM。

Pranoprofen is a PGE2 inhibitor with IC50 of 7.5 μM.(In Vitro):Pranoprofen (pretreatment for 1 h; 1 mM) has an inhibitory effect against ER stress-induced GRP78 and CHOP expression in glial cells.Pranoprofen (5-25 μM; 24 h) dose-dependently enhances Dicer expression. Additionally, Pranoprofen at 5 μM enhances H2O2 (800 μM)-induced Dicer expression in FHC cells.(In Vivo):Pranoprofen (oral administration; 4 mg/kg/16 mg/kg; 9 days) rescues Dicer expression in inflamed colon tissues, alleviates colitis and prevents colitis-associated colon cancers in C57BL/6 mice.Dicer is a key component of the RNA interference pathway and is essential for the biogenesis of miRNAs and siRNAs.

Pranoprofen (pretreatment for 1 h; 1 mM) has an inhibitory effect against ER stress-induced GRP78 and CHOP expression in glial cells.Pranoprofen (5-25 μM; 24 h) dose-dependently enhances Dicer expression. Additionally, Pranoprofen at 5 μM enhances H2O2 (800 μM)-induced Dicer expression in FHC cells.

Pranoprofen (oral administration; 4 mg/kg/16 mg/kg; 9 days) rescues Dicer expression in inflamed colon tissues, alleviates colitis and prevents colitis-associated colon cancers in C57BL/6 mice.Dicer is a key component of the RNA interference pathway and is essential for the biogenesis of miRNAs and siRNAs. Animal Model:DSS-induced acute colitis in C57BL/6 miceDosage:4 mg/kg;16 mg/kg Administration:Oral administration; 4 mg/kg/16 mg/kg; 9 days Result:Alleviated inflammation in DSS-induced acute colitis.

Pyranoprofen | Y 8004

GPCR/G Protein

Prostaglandin Receptor

PGE2

Inflammation/Immunology

——

52549-17-4

255.28

C15H13NO3

>98% (HPLC)

Ethanol: 6 mg/mL (23.5 mM); DMSO: 51 mg/mL (199.78 mM)

CC(C1=CC(CC2=CC=CN=C2O3)=C3C=C1)C(O)=O

2-(5H-Chromeno[2,3-b]pyridin-7-yl)propanoic acid

(-20℃)

With Ice Pack

≥ 2 years