Homatropine Bromide

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Homatropine Bromide 是毒蕈碱 AChR 拮抗剂，抑制内皮和平滑肌毒蕈碱受体。

Homatropine Bromide is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors.

Homatropine (20 μM) alone produces a dose ratio of 259 in atrium from guinea-pigs, and produces a dose ratio of only 95.0 when combined with Hexamethonium Bromide (HY-B0569) in atrium from guinea-pigs. Homatropine has affinities for muscarinic receptors in stomach (pA2 = 7.13) and for those in atria mediating force (pA2 = 7.21) and rate (pA2 = 7.07) responses.

Homatropine methylbromide (9 mm x 5 mm conical suppository) causes prompt blockade of the effects of vagal stimulation on pulse rate and of intravenous acetylcholine on blood pressure in rats. Animal Model:Male albino ratsDosage:9 mm x 5 mm conical suppository Administration:By suppository Result:Blocked cardiovascular responses to vagal stimulation and acetylcholine; 10-20 min after insertion of the suppository the effects of vagal stimulation over a range of 2-16 Hz, 5 V, on pulse rate was virtually abolished and remained unchanged at 45-60 min.

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Endocrinology/Hormones

AChR

mAChR (SHR-E)| mAChR (WKY-E)

Neurological Disease

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51-56-9

356.26

C16H22BrNO3

>98% (HPLC)

Water: 71 mg/mL (199.29 mM); DMSO: 71 mg/mL (199.29 mM)

CN1[C@@H]2CC[C@H]1CC(C2)OC(=O)C(C3=CC=CC=C3)O.Br

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(-20℃)

With Ice Pack

≥ 2 years