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Pifithrin-β hydrobromide
CAS No. 511296-88-1
Pifithrin-β hydrobromide ( Cyclic Pifithrin-α hydrobromide | PFT-β hydrobromide )
产品货号. M14763 CAS No. 511296-88-1
Pifithrin-α 的环状类似物和 p53 的小分子抑制剂；防止小鼠胸腺细胞中地塞米松诱导的细胞死亡，EC50 为 2.01 uM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥246 | 有现货 |
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| 5MG | ￥432 | 有现货 |
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| 10MG | ￥739 | 有现货 |
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| 25MG | ￥1507 | 有现货 |
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| 50MG | ￥2725 | 有现货 |
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| 100MG | ￥3825 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
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| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥462 | 有现货 |
|
生物学信息
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产品名称Pifithrin-β hydrobromide
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Pifithrin-α 的环状类似物和 p53 的小分子抑制剂；防止小鼠胸腺细胞中地塞米松诱导的细胞死亡，EC50 为 2.01 uM。
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产品描述A cyclic analog of Pifithrin-α and a small molecule inhibitor of p53; prevents dexamethasone-induced cell death in murine thymocytes with EC50 of 2.01 uM, sensitizes p53-deficient tumors to radiotherapy and chemotherapy and increases apoptosis in cancer cells.
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体外实验Pifithrin-α hydrobromide (PFT β hydrobromide), an inhibitor of the p53 protein, is regarded as a lead compound for cancer and neurodegenerative disease therapy. Pifithrin-α is very unstable in culture medium and rapidly converts to its condensation product pifithrin-β, the N-acetyl derivative. After 24 h, the viability assay shows that the pretreatments with 1 and 10 μM pifithrin-β exerts neuroprotective effects.
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体内实验——
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同义词Cyclic Pifithrin-α hydrobromide | PFT-β hydrobromide
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通路Apoptosis
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靶点MDM2-p53
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受体p53
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研究领域Cancer
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适应症——
化学信息
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CAS Number511296-88-1
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分子量349.2886
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分子式C16H17BrN2S
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纯度>98% (HPLC)
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溶解度DMSO: 26 mg/mL
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SMILESCC1=CC=C(C=C1)C2=CN3C4=C(CCCC4)SC3=N2.Br
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化学全称Imidazo[2,1-b]benzothiazole, 5,6,7,8-tetrahydro-2-(4-methylphenyl)-, hydrobromide (1:1)
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Pietrancosta N, et al. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1561-4.
2. Barchéchath SD, et al. J Med Chem. 2005 Oct 6;48(20):6409-22.
3. Zuco V, et al. Neoplasia. 2008 Jun;10(6):587-96.
